Friday, September 30, 2011

CSN: Cardinals hot, but not without flaws

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FOLLOW JOHN FINGER ON TWITTER

September 29, 2011, 6:00 pm

This could have been a transitional year for the St. Louis Cardinals. Perhaps even an acrimonious one, too. It began with failed contract talks between the club and future Hall of Famer Albert Pujols and ended with one of the best comebacks in the wild-card era.

The Cardinals fell 10? games behind the Brewers in the NL Central and 8? behind the Braves in the wild-card race on Sept. 5. However, the Cardinals finished the season with an 18-8 run in September, including three of four in Philadelphia and 16 wins in the last 21 games to swipe the wild-card away from the Braves.

Regardless, many of the issues that bothered the Cardinals during the regular season have not been rectified. Pujols will be a free agent at season?s end, just like his manager, Tony La Russa. In his 33rd season as a big-league manager and his 16th with the Cardinals, La Russa could be on the move at the end of the season, too.

This is La Russa?s 14th trip to the playoffs and it may have been the most difficult. Before the season even began, La Russa had to manage without ace starter Adam Wainwright, who had Tommy John surgery. To make matters worse, all-star closer Ryan Franklin inexplicably imploded and was no longer able to get hitters out. With his 1-4 record, 8.46 ERA and one save in five chances, the Cardinals released him at the end of June.

Without Franklin, the Cardinals? bullpen has been below average in 2011. Its 3.73 ERA was 11th-best in the National League and was near the bottom in opponents? slugging percentage thanks to finishing with the third-most home runs allowed. Only Washington had more blown saves than the Cardinals in the major leagues.

As a result, the starters had to pick up the slack. Wainwright was out for the year, but former Cy Young Award winner Chris Carpenter had his second straight healthy season. The Cards? starters were third in innings pitched, but really, the Cards? staff is mediocre at best. Behind Carpenter, ex-Phillie Kyle Lohse led the team with 14 wins, while lefty Jaime Garcia and veteran Jake Westbrook also posted double digits in wins.

The Cardinals are led by Pujols and the offense that led the National League in runs, batting average, slugging and on-base percentage. The Cards also struck out the least amount of any team in the big leagues.

But that doesn?t mean the team is without its issues, either.

Centerfielder Colby Rasmus, still just 24, seemed ready for a breakout season until he decided St. Louis was a little too demanding a baseball town for him. So he was traded to Toronto. Meanwhile, all-star Matt Holliday has battled an injured hand, while veteran shortstop Rafael Furcal has hamstring issues.

Lance Berkman, on the other hand, had no hang-ups. Instead, the 13-year vet posted 31 homers with a .959 OPS and a .301 batting average. In eight career postseason series, Berkman is a .320 hitter with seven homers. All-star and Gold Glove catcher Yadier Molina, also put together his best offensive season.

Regardless, the Cards still go around Pujols, so there should be no surprise that the team?s late-season surge coincided with their best player?s best month.

Pujols closed September by batting .355. During the four-game series at Citizens Bank Park two weeks ago, Pujols went 7 for 17 with a long home run that might be completing its first orbit by now. He hits particularly well against Roy Oswalt (seven homers and seven doubles in 95 career at-bats), but against Roy Halladay, Cliff Lee and Cole Hamels, Pujols is a combined 7 for 42 (.167) with two homers (both off Hamels) and four strikeouts. Against closer Ryan Madson, Pujols is 0 for 11.

Of course, regular-season numbers often have little bearing on the postseason? and vice versa. Nevertheless, last season the Phillies also faced the best offense in the National League during the NLDS and allowed three earned runs in a three-game sweep.

That?s one stat the Phillies hope holds up.

E-mail John R. Finger at jfinger@comcastsportsnet.com.

Source: http://www.csnphilly.com/baseball-philadelphia-phillies/news/Dangerous-Cardinals-not-without-flaws?blockID=569682&feedID=704

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Thursday, September 29, 2011

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Kits For Home Improvement | ICA Restoration

It is said that building a house is one time process but converting it into a home is an ever going process. It is a continuous process and one can always find room for home improvement. Every part of the house, whether interior or exterior, can be improved.

One can do home improvement in various ways. One can hire a professional service provider like an interior designer or architect. However, this option is for those who have a big budget. Alternatively you can find local carpenters, plumbers or masons to do the required work. One can easily find their contact details from local newspapers or yellow pages. These are small proprietary shops with teams of 2-4 workers. Cheapest alternative is to do the work yourself if you have the right tool kits at home.

Tool kits are sets of tools to do a specific type of work. One can get a carpentry tool kit, a plumbing tool set and so on. Most of these kits include measuring tapes, machine to drill holes, pliers, wrenches and screw drivers of various sizes. You may also get bunch of nails, screws and nuts. These tools are good enough to do some basic work like fixing a loose screw in furniture, or fix a leaking tap or repair your old garden fence.

A home plumbing kit is useful to take care of various taps, faucets, pipes and helps keeping your bathroom and toilets in a good state. Plunger is one of the simplest and most useful plumbing tools. It has been in use for centuries and still used by almost all plumbers. A few hard pushes of the plunger down the choked hole is good enough to unclog it. Also keep a good torch handy so that you can work under the kitchen sink or any other dark areas in the house. Also keep handy a good sharp saw with spare blades to cut through the metal or plastic pipes, if required.

An electric home kit also includes power testing meter apart from some of the above tools. This meter is commonly called multi mater as it can measure various electricity related parameters. Conduit installation is a common electric task which with a little practice and knowledge can be done your self. However, care should be taken to avoid any shocks. Electric kit will also include couple of wire cutters and fuses.

Carpentry DIY (Do It Yourself) kit includes various saws to cut wood. It will also have a chisel and file. You can buy glues as and when required because they easily get dried in hot weather and then are of no use. Hammers, nails, screws too are part of carpenter?s kit. With these you can loosen jammed doors or fix a loose shelf in the closet. You can also tighten various screws in the door hinges and even fix door locks.

If you have these kits at your home you can prolong the life of various things in your house and avoid heavy replacement expenses or cost of buying new things. The proverb a stitch in time saves nine aptly applies in case of home improvement too.

Source: http://www.icarestoration.com/?p=38

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Wednesday, September 28, 2011

Exclusive: CariDee English Speaks on America's Next Top Model, Psoriasis


CariDee English is a former America's Next Top Model champion, having taken home that show's top prize in December 2006.

So what better source to go to for scoop on the current All-Star cycle?

CariDee English Image

"It gives the former contestants a chance to win the title, which is amazing to watch because the girls really know now what it feels like to let the title slip through their hands," English told THG of the format. "So all of them are bringing their A game and it's exciting to watch the veterans at Top Model winner war again!"

English also faces the challenge of being a model with psoriasis, a skin condition that affects 7.5 million people and presents itself as red, scaly plaques all over one's body. She uses Stelara to help manage her psoriasis symptoms and encourages others with the disease to do the same, saying:

"Educate yourself about advanced treatment options and find a dermatologist that will work with you to manage your condition," adding:

"I strongly encourage people with psoriasis to connect with each other in-person or through online communities such as the National Psoriasis Foundation. There are millions of people living with psoriasis and we are not alone... make sure to be honest and open about the good and bad days, because these conversations will help your dermatologist understand exactly what it is that you’re going through. Reach out for the support you need when you need it the most with friends, family, your psoriasis network and your dermatologist."

Source: http://www.thehollywoodgossip.com/2011/09/exclusive-caridee-english-speaks-on-americas-next-top-model-psor/

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Great Basketball Drills to Implement in the Gameplay | Necessary ...

These days, people are very concerned about losing weight, so they start extreme diets and try to starve themselves to death in their attempt to drop a few pants sizes. Everybody knows that losing weight is very difficult and a lengthy process, which has a lot of implications and requirements. The two most important aspects of a successful diet are eating healthy food and exercising properly on a regular basis.

Sure, the market is flooded with thousands of so-called ?wonder? products that make tall claims about their effects, but in fact these meal replacements and dietary supplements are just chemicals and they will fill your body with toxins and harmful substances. If you care about your money and your health, you will have to focus on understanding your body?s needs and fulfilling them properly, while losing weight and uncovering those six pack abs.

One of the most famous diets of the present is the Jennifer Hudson weight loss program, because she was able to follow a diet which incorporated things like pizza or ice cream and still get to lose as much as 80 pounds. If you want this diet to work for you too, you should be prepared to completely change your eating habits and follow a tight schedule. This is not like any normal diet that advises people to starve themselves to death, while obtaining only short-term results. You can obtain all the nutrients your body needs and stay healthy and in shape at the same time with the right diet.

This diet is about learning how to eat and doing it according to an established plan. Discipline and a strong will are the basic requirements to obtain the expected results not just with this diet, but with any other weight loss program that requires commitment and determination for optimal results.

Apart from improving your eating habits, there is still one important condition to meet: exercising or practicing sports to burn calories and prevent food from being turned into fat tissue. You can go jogging or to the gym, if you like using fitness machines, but the most fun and relaxing way to lose pounds is to practice the sport you?re interested in.

The sport you practice is not only about losing weight, but also about spending a great time and having fun with your friends. You can learn great basketball drills to impress your friends and improve your gameplay, while staying in shape and losing those extra pounds.

If you enjoyed the article and have more inquiries about Basketball drills and Jennifer Hudson weight loss, please do not hesitate to visit us.

Source: http://necessaryarticles.com/recreation-sports/great-basketball-drills-to-implement-in-the-gameplay

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Tuesday, September 27, 2011

The Work-Study ... - Every Article Submission ? All About "Finance"

Many pupils cannot cover all of the costs of a college education. To receive financial aid, students should complete the FAFSA. As soon as the FAFSA is reviewed, the financial aid prize package could consist of money earned from a work-study program. University campuses have piece-time jobs available to pupils as a piece of the work-study program. The wages earned from these kinds of jobs are to help pay for educational expenses.

Any students seeking financial aid from the government should apply for a student loan through the Totally free Application for Federal Student Assist(FAFSA) to figure out their eligibility. Many factors are important for the eligibility for financial aid. To obtain a Pell Grant, you need to be a student without a bachelor?s degree accepted at an accredited institution of higher education and a citizen or resident alien of the United States. For federal loans, or a student loan from a private institution, all of the above apply except that one does not have to be only trying a Bachelor?s degree. Matriculate pupils are eligible as well for loans.

A Perkins Loan is one of a number of federal loans which are need-based, concluded by info within the FAFSA form. This type of financial aid is really a student loan given by the government that?s relatively low-interest for needy families.

Occasionally there isn?t enough scholarship and grant money to go around and a student must resort to taking out student loans as a form of financial aid. The very best option for these kinds of is to submit a FAFSA form to the government to measure one?s eligibility for federal loans for example the Stafford or Perkins Loans. When one receives their Student Aid Report (SAR) following review of the FAFSA form, this info might be sent to schools with a predetermined eligibility for certain amounts based upon student need.

The FAFSA form will be the Free Application for Federal Pupil Aid. This form takes you or your parent?s taxes from the previous year and surmises just how much the government thinks your family can add each year toward university. This is called your EFC, or roughly calculated family contribution. From there the school will process the financial aid presents, which can consist of Pell Grants, scholarships, and federal loans. A student loan might be essential to make up the difference between your contribution and other financial aid.

In order to locate assist online for student financial aid, there are many resources available. First of all, one might fill out their FAFSA online. This allows the federal government to evaluate your family income, allowing them to distribute suitable federal loans. Other methods to receive financial aid are applying for a student loan, that will be paid back over time. This is generally utilized to make up the difference between the federal loan and the price of university.

You could apply for federal loans if you are already in school. Financial aid is available to incoming sophomores, juniors, or seniors. Go to the FAFSA web site at www.FAFSA.ed.gov for much more information, where you will find an application for this student loan.

Related posts:

  1. Another Method To Pay For School: Work Study
  2. How A Work-Study Program Can Benefit You
  3. Paying Your Loan Early
  4. Applying For Financial Assistance Through School
  5. Everything You Want To Understand About The Pell Grant

Source: http://financecalifornias.com/6468/the-work-study-program/

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Monday, September 26, 2011

Immigration law | ruregistrar.com

Most Russian immigration to America through visas and this page will show you some information that you definitely can benefit from. Most Russian immigration to America can be made by boyfriend or business visas L-1. The fianc?e visa is a powerful tool for a successful Russian immigration to America. It provides legal access to the Russian bride and dependent children. One great thing about the L-1 for Russian immigration to America is that the Russian national purposes can usually get a green card within a year after the entry of SU Another great thing about Russian immigration to America by an L-1 visa holder to the spouse and unmarried minor children may also enter the U.S. as parents.

United States immigration law is very complex and constantly evolving. Only an Attorney at law Russia specializing in immigration law is the possibility of obtaining a positive outcome of the case. Application process for Russian immigrant visas in the United States takes place within the United States. If you are already in the United States and have legal immigration status, there is no need to leave the country for the groom, or L-1. Before the Russian immigration to America can be completed, the USCIS first to discover certain things. USCIS is the U.S. Citizenship and Immigration Services, and wants to make sure everything is legal and valid before allowing the force on the Russian Immigration to America.

Source: http://www.ruregistrar.com/immigration-law.html

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What is Compulsive Sexuality? - Sexuality and Astrology

What is Compulsive Sexuality?

Article by Dorothy Hayden

Case Study

Steve is a professional musician. A man in his 50?s, virile yet sensitive, he is sexually compulsive around fetishistic sex. Since his early teens, Steve had masturbated nearly every night before going to sleep. As he matured, his need for masturbation increased until he was masturbated five or six times a day. He found that if he did not act on these urges, he would remain ?horny? all day, which would make him restless, distracted, and irritable. When asked about his masturbatory fantasies, he related that they centered on feet, stockings, worshiping at the feet of a dominant woman to whom he would avow love, and visiting professional sex workers to whom he would also confess love. By his mid-twenties, he was routinely acting out on these fantasies. Again, if he did not act out his sexual fantasies, he would become very uncomfortable and would be unable to focus on anything except playing music during the day. When the Internet became available, he started spending multiple hours each day surfing the net, looking for fetishistic images to which he would masturbate. Stating that he was never interested in ?fucking real women?, he was eager to view websites that featured feet, legs, stockings, heels and dominatrixes.

When he would begin a romantic/sexual relationship with a woman, he would vow to stop acting out with aberrant sex to devote his attention to the girlfriend. He could, however, never bring himself to tell the ?real girlfriend? he loved her. Within a few months after he began a relationship, he would lose sexual interest in his partner and the relationship would fall apart.

At some point, he started using telephone sex services. He would enjoy having elaborate fantasy relationships with the workers and would often ?fall in love? with one of them. When he had ?maxed out? his credit cards, he applied for new ones and then ran them up their limits. He got behind in the rent, and the power company threatened to cut him off unless he paid his bill. Socially isolated, deeply in debt, and about to lose his job, Steve realized his preoccupation with sex was ruining his life, but he felt powerless to change his behavior. Moreover, he was fighting the urge to visit a dominatrix/transvestite which he felt was a significant increase in the level of deviance he required to achieve sexual satisfaction. He also was beginning to sense that pornography and phone sex no longer excited him as much as they used to. Increased levels of novelty, excitement and risk were required to achieve orgasm. At the same time he had met a woman whom he greatly admired, but for whom he had no sexual feelings despite her very real physical attractiveness. When he lost interest in her sexually and episodes of emotional intimacy would provoke anxiety, he began to examine his relationship patterns. Fearful that he was perpetuating his life-long pattern of not being able to be sexual or to have loving feelings for a real woman, he was concerned that yet another relationship would painfully fall apart. This, combined with persistent job jeopardy and chronic debt, propelled him into treatment.

Personal HistorySteve was the youngest child in the family, with a sister who was five years his senior.His sister was a bit sadistic, tormenting him with teasing when he began to develop sexually. He relayed an incident wherein he had given an ID bracelet to a girlfriend and his sister confronted him about the missing bracelet at the dinner table which incited fear in him about his projection of his mother?s enmeshed and hysterical reaction.

His mother, it seemed, was the stereotypical ?Jewish mother.? She was adamant that he not see girls who were not Jewish (and most of his girlfriends were not). When starting treatment, Steve relayed that he had a very ?loving? relationship with his mother. She would tell him that she loved him ?every 10 seconds? and would incur his guilt about abandoning her whenever he made an effort to explore his interest in girls. As treatment proceeded, he began to realize that a fear of engulfment was an underlying factor about his anxiety about true intimacy and was able to connect this to his relationship to a mother who was too insecure to allow him to become his own person. He spent his childhood feeling that he could not retain a sense of himself and still maintain his relationship to mother, whom he put on a pedestal. Unable to risk his mother?s emotionally abandoning him, he clocked himself in an armor of a ?false self?, which was a people-pleasing self. Constantly seeking validation from the outside, sexual approvable and acceptance from sex workers made him feel real, vital and alive. It defined his identity.

His love and need for mother represented a conflict for him. At some point, he began to realize how emotionally arbitrary his mother was. He could never trust her telling him that she loved him ?every 10 seconds? because she would act differently from one moment to the next, giving Steve mixed messages. What disturbed him most as a child were his mother?s rage attacks, which were unpredictable and could be triggered by almost anything. Inevitably, whenever Steve would make an attempt to appropriately separate from family, his mother would rage about an unrelated event. He sometimes would feel ?crazy? by his mother?s enmeshment and abandonment patterns.

Steve?s father worked in the hardware store that his father (Steve?s grandfather) had started and had successfully run until he sold it to cover his gambling debts. Steve?s father had intended to save his money and eventually either to buy out the hardware store?s current owner or else to open his own store. After many years, however, he was still working for little more than minimum wage, while the store?s owner would regularly rebuke him for not having his father?s knack for hardware. Steve?s father was not ready to be a father when Steve was born. Steve understood that his father was planning on leaving his mother but could not bring himself to leave her with two small children. Steve came to blame himself for being responsible for holding his father in a marriage he did not want to be in. Later he realized that his father would not have had the guts to leave. Steve noted that his father never stood up for himself or for his family, and that he never stood up to Steve?s mother. While his mother held Steve up on a pedestal, she, at the same time, demoralized his father with her constant belittling about his failure as a man.

Steve?s father died from a heart attack when he was 13. Steve felt nothing about the loss and when he went back to school he never told anyone about it. . About a year later, his mother was hit and killed by a bus after Steve asked her if she could walk the dog as a favor to him. He had wanted to stay home to look at internet porn and masturbate.

Extremes of parental depravation or indulgence have devastating effects on a child, and it is not surprising to find this dynamic in the backgrounds of many sexual compulsives.

In addition, he had a weak connection to a vulnerable father to whom he felt a guilt-inducing tie for ?holding? him to a torturous marriage to a woman who loathed and belittled his manhood. There was no port in the storm for Steve; no sustaining environment where Steve could develop an arsenal of task -orienting coping strategies. Nor did he have any social connections that could have compensated for the lack of balance and consistency required for the development of a solid, adequate sense of self. Like many sexual compulsives, he sexualized his family-of-origin conflicts and developed an internal ?split? to abide an unbearable childhood psychic reality.

As an adult, he felt he lived in two worlds ? not unlike a Dr. Jekyll and Mr. Hyde syndrome. There was a vacillating connection between fetishistic love objects in his fantasy world where he could express none- threatening love feelings and ?real? women who were his companions and intellectual equals, although he held no erotic feelings for them. He could remain alive and vital enough to succeed at a competitive career in the music industry by remaining in a dissociated ?erotic haze? which served to regulate the amount of intimacy he could tolerate. The sexually compulsive person therefore frequently alternates between the isolated and anxious clinging to both the ?fantasy? love object with whom he feels safe but dehumanized, demoralized and fraudulent, and the ?real? woman with whom he feels emotionally vulnerable, terrified of engulfment and de-erotized.

In addition to a lack of self care and the repetitive, impulsive choices that result in damaging consequences to the self, the person enslaved by compulsive sexuality is ill- equipped to value, comfort, soothe, and care for his authentic self. Indeed, he has no authentic self because he has never separated from his family-of-origin. The lack of care and nurturing from a mother who only saw him as a ?need-supplying object? for herself is his basic trauma and is acted out sexually as an adult.

With this case in mind, let us pick out specifically what makes for a description of a sexually compulsive person.

Compulsive Sexuality ? Solidifies his identity? Feels shameful? Is illicit, stolen, or exploitive? Compromises values? Draws on fear for excitement? Reenacts childhood traumas? Disconnects one from oneself? Creates a world of unreality and fantasy? Is self-destructive and dangerous? Uses conquest or power? Serves to medicate and kill pain? Is dishonest? Requires a double life? Is grim and joyless? Demands perfection? Mistakes intensity for intimacy? Requires novelty ? intensity always has to be more than the last ?hit?? Gives way to self-hatred, loneliness and despair.? Has no sexual ?boundaries?? Uses false intimacy as a way to avoid relational pain? Preoccupation and ritualizations? Is ?doing to? someone? Is devoid of communication? Has no limits? Benefits one person? Is an uncontrollable energy? Is emotionally distant

Other considerations

? Behavior leads to increasingly negative consequences but addict unable to control acting out? Denial of the behavior?s seriousness? Is the product of intense, unmet needs, coupled with the demand for perfect fulfillment and control of relational pain? Demands that life provides an illusion of reassurance and predictability by getting self-centered physiological relief? Is always a narcissistic endeavor ? people are seen as ?need-supplying objects?, not as real human beings; more interested in getting than giving? Is ephemeral ? physical orgasm provides a welcome rush of adrenaline, but by itself can only offer the brief illusion of intimacy and belonging? Sex is a conquest and abates the terrifying sense of not belonging? Sexual fantasy conjures up a perfect world of nourishment, love, generosity and tenderness.? Are trapped in the paradox of being terrified of loneliness even as they act in ways that create further loneliness? In fantasy sex, have the freedom to be vulnerable and nurtured without fear. At it?s core, sexual fantasy is a worship of self? Carry a sense of parental betrayal; parents unable to provide a positive role model of healthy intimacy? Have no ability to regulate their emotions from within? Risk relationships, financial loss, job jeopardy and physical safety? Possesses a set of irrational cognitive distortions, including ?Sex is my most important need?; ?I am basically a bad, worthless person; no one could love me as I am;? ?My needs are never going to be met if I depend on others;? ?I am valuable only if I am sexualized; being sexually desired makes me feel alive;? (Patrick Carnes, Out of the Shadows: Understanding Sex Addiction)? Have deficits in the areas of social skills, interpersonal communication, stress control, anger management and empathy for others? Learned in childhood that feelings are dangerous, so learned how to mask their feelings, even from themselves? Sexual addiction is not a moral issue; it is a coping mechanism born from childhood wounding



About the Author

Dorothy Hayden, LCSW, is a Manhattan-based psychotherapist who, for the past 15 years, has specialized in sex therapy, sexual compulsion (sex addiction) and deviant sexuality. A complete list of her articles and major-media appearances can be found on http://www.sextreatment.com

Tagged with: Compulsive ? Sexuality

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Source: http://sexualastrology.axlchen.com/what-is-compulsive-sexuality-2/

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Sunday, September 25, 2011

Speed During Soccer Training | AutoRoll - Recreation and Sports

[unable to retrieve full-text content]During soccer training, you are introduced to many different things. While many of these things focus on technique, speed is an important element in soccer as.

Source: http://recreationandsports.therefinedgeek.com.au/index.php/2011/09/speed-during-soccer-training/

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Saturday, September 24, 2011

Wealth tax red list released for the outstanding taxes : Condo.com?

Wealth tax red list released for the outstanding taxes

September 11, Tory Burch Outlet the Greek Treasury secretary WanWei Evans, jersey, plug in los thessaloniki nicky news conference announcing a new budget cuts (AFP PHOTO/SAKIS MITROLIDIS)

Greek finance minister WeiNi jersey Evangelos Venizelos Ross (11) said on February next year, will be in before a property tax collection, to make up for the 2011 2 ZhaoOu yuan (us $2.7 million) budget gap. WeiNi ze Ross said the measure is expected to help, Tory burch shoes Greek achieve its goal of reducing red this year. And elected officials to send a month less water.

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WeiNi ze Ross also released a list of enterprises, the outstanding taxes in about 6000 Greek size enterprise, between during several rooms including state-owned enterprises, government taxes were to default a total of 30 billion euros ($40.97 billion). Finance minister to urge the outstanding taxes as soon as possible, Tory Burch Reva Flats to improve the government payments enterprise financial situation.

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The Greek debt crisis, the administrative authorities had to force the tax system reform, but the territory of China by rampant tax evasion, people criticize the government forced the government to slacker case against decided to release the outstanding taxes enterprise list. According to estimates that a quarter of the country's labor minister, Tory Burch Flip Flops no tax economic activity.

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WeiNi ze Ross says, the Greek government debt to individuals and businesses tax totaling 42 billion euros ($57.36 billion), the official statistics released after in the outstanding taxes, large amount of personal list.

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According to data released, state-owned railway company (OSE Greece is among the top list of outstanding taxes), Tory Burch Handbags were to default taxes 1.26 billion euros ($1.72 billion); Athens bus company (OASA) outstanding taxes of 16.35 million euros ($22.33 million).

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Source: http://www.condo.com/Community/UserBlogPost.aspx?ID=13687

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Tecca TV: TechLife on Obama?s homebrew, 3D printing for kids, human suspended animation, and more! (Yahoo! News)


Thanks for tuning in to TechLife on Tecca TV, where we give you the 5 best technology-meets-lifestyle news stories in only 5 minutes! We like to bring a bit of Friday Fun to you each week.

Be sure to peruse the detailed show notes below to find more information on all the stories we covered in this episode. And if you missed our episode last week, be sure to check it out for our take on glowing cats, new Earth-like planets, arctic airships, and more.

As always, we would love your feedback on this week's episode of TechLife! Please let us know your thoughts in the comments, and be sure to tune in next Friday for another episode of TechLife on Tecca TV!

This article originally appeared on Tecca

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Friday, September 23, 2011

Tweeting Photos via SMS Could Revolutionize News [Twitter]

If you own a smartphone, the possibility of tweeting a photo via SMS probably means nothing to you. But, if you're still rocking a regular mobile phone, or in a country that has no mobile Internet access, sending photos via SMS is exciting news. More »


Source: http://feeds.gawker.com/~r/gizmodo/full/~3/CcU_1kciJ-s/tweeting-photos-via-sms-could-revolutionize-news

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The 14 Day Eczema Cure Will Be The Program We Will Be Looking ...

One thing we want to mention is that left untreated some individuals can actually die because of eczema. This is not to say that eczema alone can kill you, even so the side effects from your eczema can kill you like staph and bacterial infections. The only reason I mention this is so you realize that this really is a major situation and not just some red skin like many folks think. But if you could in fact find a way to heal your eczema, staph infections and also other problems will not be a concern.

One of the greatest things that I found relating to this eczema cure is that you are going to be learning methods to eliminate your eczema using all natural methods. With this program you will not be using any drugs, which is a wonderful thing because these types of drugs can also cause unwelcome side effects in your body. The creator of this program, Fay Spencer, realized this and started searching for a natural way to not only deal with but to also get rid of her eczema. And she did come across a natural cure for her eczema and is now sharing this treatment with every person.

When you browse the website for this program you will discover that there?s also a few testimonials. They are from a few people which made a decision to give Fay?s system a go and are actually glad they did. You may also be interested in some of the other guides and manuals that Fay has put in to this package. If you decide to check out the website you will be able to see the best free bonus which is one more manual that will cover other natural cures that Fay has discovered. This free guide is a listing of cures for hundreds of diseases and also illnesses that regular people suffer from each and everyday.

Fay also provides a refund to anyone that purchases this program and are not happy with it. This point alone really tends to make this the kind of program you might like to check out as you have a full 60 days to ask for your money back. This is a no questions asked refund policy, so you don?t even have to tell her the reason why you require a refund. This system itself is selling right now for $39.99, which is a very good price for a program that can teach you to heal your eczema. The reason I would recommend this system is because it shows you how to remedy your eczema naturally, and with the money back guarantee, if it does not work properly for you, you get your money back.

For additional indepth information on fat loss and physical good health please do yourself a favor and to take a look at an article on Skin Disorders or check out WebMuscleFitness to read hundreds of instructional and healthy articles on body building and cardo fitness.

Source: http://articleava.com/the-14-day-eczema-cure-will-be-the-program-we-will-be-looking-at-here.html

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Thursday, September 22, 2011

Helping Your Kids Learn Through Leapster L-Max Learning Game ...

This is a condensed piece of writing on "Helping Your Kids Learn Through Leapster L-Max Learning Game System Pink Edition" While nearly all of the time this subject matter has not been given it's appropriate share in the media however at this time common people are talking about Console Systems and sharing knowledge concerning Console Systems. Get comprehensive benefit of invaluable information in this article and please take time to comprehend it completely instead of just skimming through it.

This write-up is work of Abraham David. If you want to take this piece of writing please make sure you put a link back to this web page. Article on "Helping Your Kids Learn Through Leapster L-Max Learning Game System Pink Edition" starts after this.

Article Starts from Here:

Your kid?s education should be one of your primary priorities as a parent. You should get them the best education that you can afford, and you should also let them have time for games and toys. There is a lot of gaming consoles available in the market today but you would also want your kids to learn from the games they play.

However, not all kinds of games available for the different gaming consoles are educational. Some games are even integrated with violence, blood and gore that can negatively affect your child?s psychology. It is recommended that you should purchase games that your children can learn from.

In the past, kids learn through shaped blocks and other toys that they can physically hold. Some of these toys can prove to be dangerous. So, you want to buy them something that is safe and something that they can learn from.

It is a fact that playing is one of the best ways a child can learn. It may be logical thinking, language or it can even be math. With the right games, you can really develop your child?s intelligence. Handheld games for children have existed for a long time. However, with today?s advancement in graphics and sound technology, a lot of handheld games for children now have better graphics and better sound quality.

Notice: Please beware that everything said in this piece of writing on "Helping Your Kids Learn Through Leapster L-Max Learning Game System Pink Edition" should not be taken as advice from specialist, you should find out facts from more authentic places as well. Please ask a specialist of the relevant field. OvalEgg.com is not responsible for any damages of any kind that may arise from applying information contained in this article.

An example of an educational gaming system for children is called the Leapster L-Max Learning Game System Pink Edition. Developed by Leapfrog, you can be sure that they offer quality education and quality toys for your children.

It is a fact that learning can be boring, this is why the Leapster L-Max Learning Game system Pink Edition have took it to the next level and made the learning experience fun for children. This particular gaming system is handheld. However, you also have the option on plugging it to your TV for a much better learning experience.

Leapster L-MAX Learning Game System Pink Edition is recommended for children aged 4 to 10 years old. It also has different gaming titles that you can integrate in the gaming system as your child develops.

It has animations included where your child can easily learn how to identify and write letters and it also has games where your child can play with their favorite cartoon character. This gaming system also teaches math, and language skills for different age levels.

Here are the things that you can expect this game system to teach your kids:

? Letters
? Rhyming
? Spelling
? Phonics
? Numbers
? Addition
? Subtraction
? Counting
? Art

Depending on your child?s capability, you can effortlessly make learning easier for them with this gaming console. Besides, what more can be fun for a child that having the ability to interact with their favorite cartoon character?

No other gaming console for children offers this kind of learning experience than the Leapster L-Max Learning Game System Pink Edition.

So, if you want your child to learn and at the same time have fun, you should purchase this game system for them. With the features that this game system offers, you can be sure that your child will use it for hours to have fun and at the same time learn about things that they will usually get bored off in school.

Language, math and art skills can be developed by using this game system. This game system also has a vast game library where your children can choose which game they want to play. They can choose to play with Dora the Explorer, Scooby Doo, SpongeBob SquarePants and they can even choose to play other different games.

There are different games for different age levels. All you need to do is choose which of the games can accommodate your child.

So, if you want your child to have fun and at the same time learn something while they play, the Leapster L-Max Learning Game System Pink Edition is your choice. With this game system, you can expect your child to learn faster and play at the same time. Think of investing in this game system as investing in your child?s education.

Thanks for reading this write-up. If you are planning to take this write-up for your use in any way, please link back to this page. I hope you loved what I wrote on "Helping Your Kids Learn Through Leapster L-Max Learning Game System Pink Edition". I would be pleased to know what you think concerning it, negative or positive. Please put down a comment below and show me you are alive.

Article Source with Title: Helping Your Kids Learn Through Leapster L-Max Learning Game System Pink Edition
Article Source URL: http://ovalegg.com/gaming/console-systems/helping-your-kids-learn-through-leapster-l-max-learning-game-system-pink-edition

Source: http://ovalegg.com/gaming/console-systems/helping-your-kids-learn-through-leapster-l-max-learning-game-system-pink-edition

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Wednesday, September 21, 2011

Health and Fitness ? Rand study finds less crime near pot ...

Medical marijuana dispensaries ? with storerooms of high-priced weed, registers brimming with cash and some clientele more interested in getting high than getting well ? are often seen as magnets for crime, a perception deepened by a few high-profile murders.

But a report from the Rand Corp. reaches a startling conclusion: The opposite appears to be true.

In a study of crime near Los Angeles dispensaries ? which the investigators call the most rigorous independent examination of its kind ? the Santa Monica-based think tank found that crime actually increased near hundreds of pot shops after they were required to close last summer.

?What I would take away from it is maybe there should just be a little bit less fear about having dispensaries,? said Mireille Jacobson, a health economist who was the lead researcher. ?Hopefully, this injects a little bit of science into the discussion.?

The researchers compared the 10 days before the city?s medical marijuana ordinance took effect June 7, 2010, with the 10 days after, when many of the more than 400 illegal dispensaries shut down ? if only briefly.

They found a 59% increase in crime within three-tenths of a mile of a closed dispensary compared to an open one and a 24% increase within six-tenths of a mile.

The city attorney?s office, which has argued in court proceedings that the number of dispensaries needs to be reduced to deal with ?well-documented crime,? called the report?s conclusions ?highly suspect and unreliable,? saying that they were based on ?faulty assumptions, conjecture, irrelevant data, untested measurements and incomplete results.?

In particular, the office challenged the idea that most dispensaries closed June 7, 2010, and were not open for at least 10 days. And it offered its own conjecture for the rise in crime: infighting among collective members, increased traffic for pot fire sales and customers disgruntled to find their dispensary closed.

Jacobson said Rand did not assume dispensaries shut down exactly on that date and said that, if more of them closed earlier or later, it would mean only that crime increased more than the report found.

The researchers acknowledge that the results are subject to a large margin of error, so the increase in crime within less than a third of a mile could range from as low as 5.4% to as high as 114%.

?These are noisy data over a short period of time,? Jacobson said. But she noted that the numbers, which were subjected to complex statistical analyses, clearly show crime increased.

The researchers did not try to draw conclusions on why crime increased, but offered the hypothesis that dispensaries may heighten security in the areas around them because they employ cameras and guards, increase late-night foot traffic, replace illicit street sales and draw heavier police patrols.

In a review of crime statistics from 2009 ordered by Los Angeles Police Chief Charlie Beck, the LAPD found that banks were much more likely to be robbed than dispensaries.

Cmdr. Andrew Smith, a department spokesman, said the LAPD had not yet reviewed the report, but would do so.

The Rand report notes that police departments in Denver and Colorado Springs, Colo., also studied crime around dispensaries and found no evidence that they attracted crime.

None of this surprises dispensary owners or their lawyers, who note that their surveillance records are sometimes requested by police to investigate crimes unrelated to selling marijuana.

?It?s some empirical evidence that demonstrates that the security measures that make it safe for patients to obtain their medical marijuana also serve the community,? said David Welch, a lawyer who has represented many Los Angeles dispensaries.

Yamileth Bolanos, who runs PureLife Alternative Wellness Center on South La Cienega Boulevard and also is president of the Greater Los Angeles Collectives Alliance, said, ?I know that there?s no crime around here. We watch everything.?

But Steve Whitmore, a spokesman for the Los Angeles County Sheriff?s Department, strenuously disagreed with the report?s conclusions.

?Every time we shut down a dispensary, the crime and the disorder decrease,? he said.

The report looks at such crimes as thefts and assaults, but not ?disorder,? nuisances such as loitering, double parking, loud noises and graffiti that sparked anger among neighborhood activists. Whitmore said those complaints are often what causes the department to act.

Eagle Rock, which has about a dozen dispensaries, has long been one of the city?s pot hot spots.

Michael Larsen, president of the neighborhood council, said he only knows of one dispensary-related crime ? an armed robbery ? but has heard countless complaints from irritated neighbors.

He said most of the dispensaries that initially closed last summer have reopened, defying the city.

?Our main concern is the crime of illegal dispensaries illegally selling marijuana,? Larsen said. ?That?s the crime that we?re concerned about.?

john.hoeffel@latimes.com


Article source: http://feeds.latimes.com/~r/latimes/news/local/~3/KsCX95QAMIU/la-me-0928-marijuana-dispensaries-20110921,0,7776989.story

Related posts:

  1. Medical pot users say their needs are ignored as dispensaries closed
  2. Poll: Is Michigan better off without medical marijuana dispensaries? ? The Saginaw News
  3. NEW: Area marijuana dispensaries order to cease activities
  4. Medical marijuana timeline
  5. Court opinion may impact local medical marijuana dispensaries ? Sentinel

Source: http://medicaltips.biz/2011/09/21/rand-study-finds-less-crime-near-pot-dispensaries/

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Video: Will Easing Credit Standards Fix Housing?

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Source: http://www.msnbc.msn.com/id/21134540/vp/44598181#44598181

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Tuesday, September 20, 2011

Source: Sheen, Warner nearing deal on lawsuit

Charlie Sheen presents the award for outstanding lead actor in a comedy series at the 63rd Primetime Emmy Awards on Sunday, Sept. 18, 2011 in Los Angeles. (AP Photo/Mark J. Terrill)

Charlie Sheen presents the award for outstanding lead actor in a comedy series at the 63rd Primetime Emmy Awards on Sunday, Sept. 18, 2011 in Los Angeles. (AP Photo/Mark J. Terrill)

(AP) ? Former "Two and a Half Men" star Charlie Sheen and the studio that fired him are drawing closer to a deal to end their legal dispute.

According to a person familiar with the talks, Sheen and Warner Bros. were near an agreement but still at work on it Monday. The person was not authorized to comment publicly and spoke on condition of anonymity.

Calls to Sheen's attorney were not returned. In a statement, the studio said no deal had been reached and declined further comment.

Sheen filed a $100 million lawsuit for wrongful termination against Warner after his firing, which followed bitter public tirades directed at the studio and the show's executive producer.

A judge ordered arbitration in the case, with a status report set for December.

The Los Angeles Times reported that final touches are being put on a deal that would give Sheen about $25 million to settle out of his contract.

Sheen was the highest-paid actor in television, with a per-episode salary reported to be between $1.2 million to $2 million.

His clash with producers cut short last season for the CBS series that is TV's highest-rated comedy.

"Two and a Half Men" returned to the air Monday with Ashton Kutcher joining the cast as a new character. He plays an Internet billionaire who decides to buy the house that had been owned by Sheen's now-deceased character.

In a recent turnaround, Sheen has been making conciliatory gestures toward his former show.

Appearing at Sunday's Emmy Awards as a presenter, he addressed the "Two and a Half Men" cast and crew, saying, "I wish you nothing but the best for this upcoming season."

In an interview with Matt Lauer on "Today" last week, the actor known for his hard-partying life said he didn't know how to "put out the fire" when he was fired and began a manic round of media appearances talking about "tiger blood" and "winning."

___

AP Entertainment Writer Anthony McCartney contributed to this report.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/4e67281c3f754d0696fbfdee0f3f1469/Article_2011-09-19-TV-Charlie%20Sheen-Lawsuit/id-33e833ff64b342ccbb984532ccc5c387

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First Video Game Systems to the Latest in Gaming Consoles | Oval ...

Checkout the article below on "First Video Game Systems to the Latest in Gaming Consoles" Not countless citizens recognize about "Console Systems" subject matter because media has not bothered plus people related with this subject have not been vocal enough. Nevertheless that's shifting at the moment, more people are coming to understand in relation to Console Systems because of spread of media outlets. Get thorough advantage of invaluable knowledge in this piece of writing and please take time to appreciate it wholly instead of just skimming through it.

The writer Abraham David is responsible for composing this write-up Please link to this page if you take this piece of writing for any purpose. Article on "First Video Game Systems to the Latest in Gaming Consoles" starts after this.

Article Starts from Here:

The history of video games has come a long way. Today, you will see video game consoles integrated with state-of-the-art graphics technology and amazing sound quality that can rival your home entertainment systems. There are even gaming consoles that has different features that can rival your home PC.

For example, you will find that some gaming consoles available today have realistic graphics and Hollywood-like acting. Computer generated 3D characters even contains facial expressions and body movements almost similar to the real thing.

If you play with these consoles, you will see that the characters in it move very much like real people. But, in fact, these characters are the product of the latest 3D technology available. Not only that, characters in these games even have human like features. Some even have beards, different eye colors, and some even have hairs that moves just like the real thing.

Other integrated features that you will see in some gaming consoles available in the market today are the memory cards, where you can save your game progress, joysticks and steering wheels to add a little more realism to driving and flight simulation games, simulated guns to add realism to shooting games, and even vibration feedback to controls.

There are even gaming consoles available in the market today that can be connected to the internet. With these feature, you can join multiplayer games in the internet and play with other people from all over the world. So, if you get bored fighting AI (artificial intelligence) from regular games, you can buy a game that is available for massively multiplayer online role playing games or MMORPG.

However, before you go out and buy the real thing, you should know where all these games started. Just like any other invention, gaming consoles or gaming systems started out as having rough graphics, simple sounds and very simple game play.

In the early years of video game systems, you will find that it all started out in a simple game that was called ?Tennis for Two?. This particular video game was introduced back in 1958 and was consisted of two horizontal lines across the screen, and a short perpendicular line that represented the net.

This particular game was the root of all video games and from here, video game developers started competing and producing different games and came to the point of having great graphics and sound quality.

In the mid 70s, a company called Atari came out with a video game system that revolutionized the world of video games. It was called the Video Computer System or VCS. This system became one of the hottest selling gaming systems in its day. As you see today?s latest gaming system, you will find it hard to believe that people even bought these things.

Warning: Whatever thing within this piece of writing is personal opinion of its author on "First Video Game Systems to the Latest in Gaming Consoles", you have to carry out your own investigation to come up with accurate facts. Please ask a specialist of the relevant field. OvalEgg.com is not responsible for any damages of any kind that may arise from applying information contained in this article.

However, you have to consider the fact that in the past, because of the early technology in graphics and sounds, and 3D graphics were virtually non existent, these video gaming systems were considered as state-of-the-art. And, many people enjoyed playing with it. If you were born in this era, and played with these video game systems, you know how much fun it is to play with.

Integrated with simple graphics, simple sound effects and simple game play, it was relatively easy to play with. The whole family can really spend hours on end to play with video game systems in the past. Everyone can play with these simple machines, even children.

Today, since game developers are taking games to another level, adding realistic graphics and realistic sounds, each game are now rated by the ESRB or the Entertainment Software Rating Board. You will see that each of the gaming title will contain letters, such as E, T, M, and AO. These letters represent on who can play the game. E represents Everyone, T represents Teens only, M for Mature gamers, and AO represents Adults Only.

More and more games today are integrated with realism of violence and gore where it can really affect your child?s psychology. This is why it is important for you to check the ESRB rating before buying a particular game.

There are even games available today that can recreate the battlefield in World War II. You can even see bodies around the simulated Normandy beach that are either decapitated or a realistic person spurting blood calling out for a medic.

You can easily see how long video game systems have come in terms of graphics and sound quality.

Thanks for reading this article. Please link to this webpage if you want to use this article anywhere. I hope you appreciated what I wrote on "First Video Game Systems to the Latest in Gaming Consoles". I would be glad to know what you think concerning it, negative or optimistic. Please put down a comment below and show me you are alive.

Article Source with Title: First Video Game Systems to the Latest in Gaming Consoles
Article Source URL: http://ovalegg.com/gaming/console-systems/first-video-game-systems-to-the-latest-in-gaming-consoles

Source: http://ovalegg.com/gaming/console-systems/first-video-game-systems-to-the-latest-in-gaming-consoles

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Monday, September 19, 2011

Take A Structured Settlement Or One-time Lump Sum Cost ...

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Source: http://cybersite69.info/personal-finance/23177-take-a-structured-settlement-or-one-time-lump-sum-cost

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Sunday, September 18, 2011

The Benefits Of Getting A Help From Bonafide Pest Control Services ...

Pests are unwanted organisms which makes our life much more challenging. It is a challenge since it definitely takes a lot of aspects to fall into place for effective, long-standing pest control and removal. When you own a property it is your aim to keep them valued through the years.

Pest simply comes into your abode without your notice and it may already destroy any of your property before knowing that these undesirable living creatures exist. It might be too late when you identified pest infestation which makes it much more difficult to do away with. The main cause of such occurrence is failing to check any possibility of infestation. People missed to look beneath the surface where pests are located, in some hidden places or somewhere else where they in all probability swarmed.

Pest infestation is one of the most commonly encountered complications by each and every home owner. It is found everywhere and people have been finding the best solution to it. We even get hesitated to call a pest control company for often times we think that there are effective remedies in handling pests by our own. But most of the time it never worked just as we wanted it done. It may either be ineffective utilization or ineffective method. You might have done all efforts but the problem remained unsolved. If you think of handling the task by yourself or spraying your entire house with insecticides, think about the hazard that it can cause you and your family.

Extermination of pests can certainly be a serious problem and a major household issue to resolve. In lieu of this, experimentation and mental concoction cannot help us successfully exterminate the pests for a hundred percent. Pests are tricky and there are things about them that are definitely puzzling. With regard to this matter, a pest control service that has well known expertise and has already existed for long years is highly recommended. Beware of the bogus pest control company who tries to cheat consumers.

It is a nice start to collect as many pest management companies then feel free to inquire them with their services such as safe chemicals or pesticides that they utilize for the pest extermination, health security of every family members and the period of their pest eradication and home treatment. These are only some of the basic questions that could serve as a good reference to come up with a very good decision. You can actually perceive a good pest management by how they operate.There is lots of filtering to make before arriving with a very wise decision where to put our full trust. Managing pests are actually a complicated task. It would be even more challenging to find a competent pest control and we must be careful enough to hire the most qualified pest control and removal service.

Hire the most reliable Pest Control Company. Log on to Adams Pest website to read more information about their pest control treatment services.

Source: http://articlesprofitable.com/home-improvement/the-benefits-of-getting-a-help-from-bonafide-pest-control-services

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Real Estate Investment in Nigeria | Mortgage Refinancing

Title

Imuetinyan Adams

Nigeria has an area of ??over 970,000 km square and a population of 150 million people and the rapid growth of urbanization, making it one of the best places to invest in real estate. There is great potential in the Nigerian real estate market. Nigerian real estate market has also increased, with the potential to GDP of Nigeria. Knowledge of real estate investments among different individuals and investors in Nigeria spreads. With the large number of multinational companies and industrial investors in Nigeria growing in the country that is blessed with many natural resources flow. Investors pay more in demand more housing, which also helps to stimulate the real estate market Nigerian.

So what are the fundamentals of real estate in Nigeria?

real estate allows the huge amount of income for investors and owners to produce, as the capital value of a property with estimates also help investors time.realestate shield against loans mortgages and long-term in Nigeria. It adapts the housing stock in Nigeria and also to solve the problem of housing needs and demands.realestate in Nigeria also contributed to the private housing sector and increase the tax base for the government.

Real Estate Investments could buy clothes fresh or existing homes. So also with other investors, and part of the regular income of the property market in Nigeria, these factors are taken into consideration when buying a property to be.

[1] The location of the property.

[2] The primary purpose other property

[3] The demand for housing and real estate

Another real estate major is realestate.hotels shopping and leisure, shopping centers, etc. all fall into this category, it has...

often been one of the best investments of the under active real estate experts. Demand for small apartments, 2-4 bedrooms and shops are also in high demand in the market and can be a good real estate investment in Nigeria. Medium-term properties are better investment opportunities because they are easier to rent and buy are also easier to sell / re-sale. Real Estate is growing rapidly in Nigeria, every person who wishes to engage in real estate investing, whether professional or not professional can do it in different ways depending on his / her financial situation. Did you find this article useful? If you more about real estate, real estate, real estate articles and other resources, go to . com / to browse through our extensive and constantly updated real estate listings for sale or rent in big cities like Lagos Nigeria, Portharcourt, Abuja, Calabar and real estate listings from all over the world. About

the author with a powerful blend of features, the variety of articles, resources and information, Adams a good collector and distributor of unique and interesting information, it is currently the owner the http://www.patosrealestateguide.com , a website that peiple assets available for real estate including houses and other real estate, lease or rent in varios parts the world gives.

Source: http://mortgagerefinancing.howto-101.com/mortgage-refinancing/real-estate-investment-in-nigeria/

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Saturday, September 17, 2011

T cells making brain chemicals may lead to better treatments for inflammation, autoimmune diseases

T cells making brain chemicals may lead to better treatments for inflammation, autoimmune diseases

Friday, September 16, 2011

Scientists have identified a surprising new role for a new type of T cell in the immune system: some of them can be activated by nerves to make a neurotransmitter (acetylcholine) that blocks inflammation. The discovery of these T cells is novel and suggests that it may be possible to treat inflammation and autoimmune diseases by targeting the nerves and the T cells. The study was published this week in Science.

"The discovery that 2 percent of T cells can make acetylcholine under the control of nerves gives a new insight into how the nervous system regulates immunity," said Kevin J. Tracey, MD, president and chief executive officer of The Feinstein Institute for Medical Research, and principal investigator of the study. "The arrival of electrical signals from nerves activates these specialized T cells to produce the acetylcholine necessary to block inflammation, and protect against damage. It is possible to transfer these cells to cross-protect mice from inflammation, and to control these T cells by electrically stimulating the nerves directly."

The present study followed years of work from Dr. Tracey's lab that identified the role of the vagus nerve, named for its wandering course from the base of the brain to the liver, spleen and other organs, in blocking inflammation. Applying electrodes to stimulate the vagus nerve blocked the release of tumor necrosis factor (TNF) and other cytokines that underlie the tissue damage in arthritis, inflammatory bowel disease and other syndromes. Stimulating this nerve pathway led to increased production of acetylcholine, a neurotransmitter that binds to the alpha 7 nicotinic acetylcholine receptor. Activating this receptor on macrophages blocked the release of immune molecules (the cytokines,) suggesting a novel strategy for developing anti-inflammatory agents.

But these results raised an important question because the nerve fibers in spleen release norepinephrine, another neurotransmitter, but not acetylcholine. The search for the cells that produce acetylcholine led these investigators to use "nude" mice, devoid of T cells. Then they examined the spleen cells that make acetylcholine and that led them to a subset of T cells. Transferring these acetylcholine producing T-cells into nude mice restored the vagus nerve circuit that blocked inflammation.

"Our results point to a population of acetylcholine-synthesizing memory T cells in spleen that is integral to the function of the inflammatory reflex, the nerve circuit that regulates inflammation and immunity," said Dr. Tracey. "It is as if these T cells occupy a nerve-like function in this important circuit."

It should be possible to target these T cells and to modulate this neural circuitry to develop therapeutic modalities for inflammatory and autoimmune diseases. In the future, it may be possible to isolate these T cells and exploit their anti-inflammatory activity. In the meantime, there is a more direct route to use this discovery for therapy. Rheumatoid arthritis patients in Europe are being studied in clinical trials where vagus nerve stimulators are implanted and turned on to stimulate this circuit and suppress inflammation.

###

North Shore-Long Island Jewish (LIJ) Health System: http://www.northshorelij.com

Thanks to North Shore-Long Island Jewish (LIJ) Health System for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

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Source: http://www.labspaces.net/113455/T_cells_making_brain_chemicals_may_lead_to_better_treatments_for_inflammation__autoimmune_diseases

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Nature turns the tables on 'Contagion' plot

Marvin Moriarty / USFWS

The white fungus growing on the snout of this little brown bat in Vermont's Greely Mine is the telltale sign of the bat-killing white-nose syndrome.

By Alan Boyle

The hit movie "Contagion" focuses on a fictional killer outbreak that spread from bats to humans, but a real-life killer is taking the reverse route.

The Hollywood outbreak is based on a real pathogen, the Nipah virus, which originates in bats and?can be?passed through pigs to humans. The so-called paramyxovirus has been implicated in more than a dozen outbreaks in South Asia. The filmmakers behind "Contagion" merely turned up the dials on the bug's virulence to produce the plot's pandemic.

The real pandemic is afflicting bats, not humans. But biologists are seeing evidence that humans?are behind the spread of Geomyces destructans, the fungus that's linked to the bat-killing disease known as white-nose syndrome. In some areas of the northeastern United States, white-nose syndrome is wiping out 90 to 100 percent of the brown-bat population.


Scientific sleuths?have traced the disease to the batty equivalent of "Patient Zero": a cave in upstate New York where bats with white noses were first noticed in 2006. When bats started dying, the connection to the white nose led to a determination that Geomyces destructans was playing a role.

"Scientists in Europe said, 'We have bats that are exhibiting similar symptoms, but we're not having the same problem with mortality,'" said Ann Froschauer, a spokeswoman for the U.S. Fish and Wildlife Service who focuses on white-nose syndrome. "One of the leading hypotheses is that recreational cavers potentially brought the fungus from Europe and carried it here."

The suspicion is that fungal spores survived the trip and took root in the New York cave, where the cold and damp conditions were well-suited for the fungus. The effect on bats in the Northeast was eerily similar to the "Contagion" virus' effect on Hollywood actors.

"Once this fungus made its way into our caves in the U.S., it was the 'perfect storm,'" Froschauer explained. "The environmental conditions were right for the fungus to start growing, and bats here don't have any immunity."

The bats were more vulnerable because they were hit by G. destructans while they were hibernating, when their immune reactions?were suppressed. And even if one batch of bats is wiped out, the fungus can remain in the caves, waiting for the next wave of bats to move in and spread the disease.

USFWS

This map tracks outbreaks of white-nose syndrome since 2006.

So far, biologists have found signs of white-nose syndrome in 17 states and four Canadian provinces. An international?task force, led by the Fish and Wildlife Service and including representatives from more than 100 agencies and organizations, is trying to figure out what to do about the problem, Froschauer said. Among the potential options: holding bats in captivity over the winter to keep them away from the fungus, closing caves to human visitors, developing antifungal treatments, and even cryopreservation of bat sperm and eggs to allow for in vitro reproduction.

Wouldn't the world be better off without bats? Although you might not know it from their Hollywood image, bats do way more good than harm. No joke: A study published in the April 1 issue of the journal Science?pointed out that bats are "voracious predators" of insects that include many crop and forest pests. Without bats, North America's economy would suffer agricultural losses amounting to more than $3.7 billion a year, the researchers said. Some have called them the "unsung heroes of organic farming."

Froschauer?sees "Contagion" as an opportunity to do some?consciousness-raising about the fate of a species that doesn't?usually get much sympathy.

"Historically, they've always gotten a bad rap, and especially at this time of year, when we're often dealing with rabies reports," she told me. "In popular culture, they've always had this negative image."

Actor Matt Damon talks about his latest film, "Contagion," which is about an unknown virus that spreads around the world, and talks with ?TODAY's Matt Lauer about what would happen if the premise was real.

Ali Khan, an assistant surgeon general who leads the Office of Public Health Preparedness and Response at the Centers for Disease Control and Prevention, agrees that bats are classic bad guys.

"They make the best bogeymen, no doubt about it," he joked. "Better than Freddy Krueger."

Nipar virus and rabies aren't the only pathogens linked to bats, Khan pointed out. Researchers believe that fruit bats are the natural reservoir for the Ebola and Marburg?viruses, which cause?deadly hemorrhagic fevers in humans. Bats are also thought to be a natural host for?viruses similar to the one that?causes severe acute respiratory syndrome, or SARS.

But bats aren't the only suspect when it comes to species-jumping diseases. The list also include pigs and birds?(implicated in 2009's global outbreak of H1N1 swine flu) as well as monkeys (implicated in the?long-running HIV epidemic),?mice (linked to hantavirus) and rats (linked to the Black Death?in the Middle Ages).

Khan told me that "Contagion" has stirred up a lot of interest among the press and the public in the question, "Could this really happen?"

"Not only 'could this really happen,' but it routinely happens," he answered, "not just to the magnitude seen in the movie ? except perhaps during the 1918?flu pandemic or the Black Death."

Like Froschauer, Khan sees "Contagion" as a teachable moment for epidemiologists ? and now that he's seen the movie, he gives it a big thumbs-up. "They did as good a job as you could expect for Hollywood," he said.

That shouldn't be surprising when you consider that the film's actors visited the CDC headquarters in Atlanta to chat with Khan and other experts. "When Kate Winslet said, 'This is what an R-naught is,' I thought, 'I taught her that!'"?Khan said.

Khan?realizes that Hollywood requires villains as well as heroes to tell a good story, but he nevertheless wanted to clear up a?couple of things about the way the movie portrayed epidemiologists doing their jobs:

  • "In the movie, the Department of Homeland Security comes off as the bogeyman, at least in the early part of the movie. In our operation, there's excellent collaboration with Homeland Security and particularly with FEMA."
  • "It seems like there's just a?handful of people who solve this whole?mystery,?and that definitely isn't true to form. There are hundreds of people involved in this operation. We don't send Kate Winslet all by herself to deal with a global pandemic."

Then Khan?had a darker thought. "Maybe that's the future situation, if there are continued?CDC [budget] cuts," he said. "There will be no one available to go out and deal with pandemics."

Now that would?be?a scary movie.

More about?'Contagion,' bats and public health:


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Source: http://cosmiclog.msnbc.msn.com/_news/2011/09/14/7763706-nature-turns-the-tables-on-contagion-plot

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